Striatal and extrastriatal microPET imaging of D2/D3 dopamine receptors in rat brain with [18F]fallypride and [18F]desmethoxyfallypride

Striatal and extrastriatal microPET imaging of D2/D3 dopamine receptors in rat brain with [¹⁸F]fallypride and [¹⁸F]desmethoxyfallypride.

In this study, we compared two different D(2/3) receptor ligands, [¹⁸F]fallypride and [¹⁸F]desmethoxyfallypride ([¹⁸F]DMFP) with respect to the duration of the scan, visualization of extrastriatal receptors, and binding potentials (BP(ND) ) in the rat brain. In addition, we studied the feasibility of using these tracers following a period of awake tracer uptake, during which the animal may perf...

EFFECTS OF CATECHOLAMINES ON DOPAMINE AND SEROTONIN SYNTHESIS IN RAT BRAIN STRIATAL SYNAPTOSOMES: THE ROLE OF PRESYNAPTIC RECEPTORS AND THE SYNAPTOSOMAL REUPTAKE MECHANISM.

The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...

Striatal and Extrastriatal Dopamine D2/3 Receptors Studied with [11c]raclopride and High-resolution Pet

Physiological and Pharmacopathological Role of Dopamine Receptors and Brain Dopamine Systems

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Extrastriatal Dopamine D2/3 Receptors in Schizophrenia

Several lines of studies on schizophrenia have suggested abnormalities in dopaminergic neurotransmission and dopamine receptor densities. The aim of this study was to evaluate putative alterations of the dopamine D2/3 receptor density in extrastriatal brain regions among drug‐naïve schizophrenic patients compared to healthy subjects, to compare drug‐ induced extrastriatal dopamine D2/3 receptor...